Evaluation of Adverse Drug Reaction

Monitoring System in AMC

Ja-Eun Kimo, Seoung-Lan Kim# , Jae-Youn Kim# , Yang-Sook Na, Hee-Bum Moon#, Hye-Young Shin

Department of Pharmacy, Asan Medical Center, The Committee of ADR monitoring#

OBJECTIVE : The aim of this study is to evaluate the efficacy of ADR

monitoring system in AMC, and to find solutions for improving its quality.

METHODS : EMR review was performed on the subset of all ADR monitoring data from March through August 2006. The number of inpatients during the same period was 49,630, and 390 allergy reports with ADR being severe as well as systemic were closely analyzed.

MEASUREMENTS : The examination of causative agents and ADR-related clinical manifestations was conducted, and so was the evaluation of the accuracy of ADR reports by comparing those assessed results with contents of allergy alert. In addition, how frequently the same agents were repeatedly administered was thoroughly studied in order to evaluate the efficacy of the monitoring system.

RESULTS : 2,931 ADR alerts (5.9%) came up in 2,806 out of 49,630 patients. Antibiotics and NSAID were reported as the most frequent agents, and anti-cancer drugs were involved in 27.8% of the in-house ADR. It was found that only 4 adverse reactions (1.02%) were caused by administering the same medicines, which means significant decline in ADR, compared with the previous rate of 15% with no monitoring systems.

CONCLUSION : ADR monitoring system has proved effective in preventing both re-administration of causative drugs and ADR induction. Meanwhile, in order to make sure that alerting works out better, continuous quality improvement must be made, leading up to constant efficacy and acceptance of CPOE (Computerized Physician Order Entry) decision support.