The safety, tolerance, and clinical efficacy of

total parenteral nutrition: comparison of

a fish oil-based TPN with olive oil-based TPN

Sang-Mi Buo, So-Jung Yoon, Jae-Yeon Kim, Young-Chun Song and Hye-Sun Gwakª
Department of Pharmacy, Asan Medical Center ,College of Pharmacy, Ewha Women's Univ.ª

There are many comparative studies about the hepatic integrity between lipid emulsions and most studies found hepatic integrity was well retained with the administration of fish oil-based lipid emulsion.

So, we compared fish oil-based TPN with olive oil-based TPN for the safety, tolerance, and clinical efficacy in SICU patients. Patients were randomized to receive TPN over 5 postoperative days including either fish oil-based TPN or olive oil-based TPN. Safety and tolerance parameters were measured with AST, ALT, ALP, T-bilirubin and albumin. Clinical efficacy was monitored by the length of ICU stay. The fish oil-based TPN group (group A, n=16) and olive oil-based TPN group (group B, n=16) were similar with their demographic characteristics and surgical intervention types. There were no significant differences in safety and tolerance parameters at day1(D1), day3(D3) and day5(D5) between two groups; AST (group A vs.group B (IU/L); D1 34±16 vs.35±14, D3 39±23 vs.30±17, D5 42±29 vs.31±18), ALT (D1 26±19 vs.21±16, D3 29±23 vs.19±11, D5 34±29 vs.20±12), ALP (D1 78±43 vs.70±34, D3 93±61 vs.74±29, D5 110±82 vs.91±43), T-bilirubin and albumin.

Total calorie (21.8±6.1 vs.25.4±5.9kcal/day) and protein (0.9±0.3 vs.0.8±0.2g/day) were also similar. No difference was observed in the length of SICU stay between the two groups.

Based on the results, both fish oil-based TPN and olive oil-based TPN were well tolerated in SICU patients. Large studies are needed to demonstrate the effects of fish oil-based TPN in critically ill patients.

주제어 : total parenteral nutrition(TPN), fish oil-based TPN, olive oil-based TPN, SICU