한국병원약사회
[2011 추계] The safety, tolerance, and clinical efficacy of total parenteral nutrition: comparison of a fish oil-based TPN with olive oil-based TPN | ||
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The safety, tolerance, and clinical efficacy of total parenteral nutrition: comparison of a fish oil-based TPN with olive oil-based TPN
Sang-Mi Buo, So-Jung Yoon, Jae-Yeon Kim, Young-Chun Song and Hye-Sun Gwakª
There are many comparative studies about the hepatic integrity between lipid emulsions and most studies found hepatic integrity was well retained with the administration of fish oil-based lipid emulsion.
So, we compared fish oil-based TPN with olive oil-based TPN for the safety, tolerance, and clinical efficacy in SICU patients. Patients were randomized to receive TPN over 5 postoperative days including either fish oil-based TPN or olive oil-based TPN. Safety and tolerance parameters were measured with AST, ALT, ALP, T-bilirubin and albumin. Clinical efficacy was monitored by the length of ICU stay. The fish oil-based TPN group (group A, n=16) and olive oil-based TPN group (group B, n=16) were similar with their demographic characteristics and surgical intervention types. There were no significant differences in safety and tolerance parameters at day1(D1), day3(D3) and day5(D5) between two groups; AST (group A vs.group B (IU/L); D1 34±16 vs.35±14, D3 39±23 vs.30±17, D5 42±29 vs.31±18), ALT (D1 26±19 vs.21±16, D3 29±23 vs.19±11, D5 34±29 vs.20±12), ALP (D1 78±43 vs.70±34, D3 93±61 vs.74±29, D5 110±82 vs.91±43), T-bilirubin and albumin.
Total calorie (21.8±6.1 vs.25.4±5.9kcal/day) and protein (0.9±0.3 vs.0.8±0.2g/day) were also similar. No difference was observed in the length of SICU stay between the two groups.
Based on the results, both fish oil-based TPN and olive oil-based TPN were well tolerated in SICU patients. Large studies are needed to demonstrate the effects of fish oil-based TPN in critically ill patients.
주제어 : total parenteral nutrition(TPN), fish oil-based TPN, olive oil-based TPN, SICU
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